- Arteriosclerosis
- Arthralgia
- Decline in Physical Function
（Frailty）
Aiming for improvement and prevention of the above conditions
Stem Cell Therapy
Lifelong health
through the power of regenerative medicine
The Promising Potential of Stem Cell Therapy
Across Various Fields
Stem cell therapy is a form of regenerative medicine that aims to restore damaged tissues or lost functions by replenishing “stem cells,” which are essential for tissue repair and regeneration.
These cells play a vital role in healing and restoration, and clinical research is being conducted across a wide range of fields—from the treatment and prevention of serious illnesses to cosmetic applications such as hair growth and skin rejuvenation.
Recognizing the powerful potential of stem cells, the Tokyo Midtown Center for Advanced Medical Science and Technology offers stem cell therapy for the treatment of conditions such as“arteriosclerosis,” “arthralgia,” “frailty*,”and “skin problems,”with the goal of preventing serious illnesses and improving physical function.
*Frailty refers to the transitional stage between a healthy state and the need for nursing care.
As people age, they may experience diminished physical strength, reduced mobility, and a need for assistance, even in the absence of specific illnesses.
This deterioration of physical and mental function is referred to as frailty.
Midtown Clinic Group offers stem cell therapy
for individuals with concerns including:
Elevated blood pressure
High blood sugar
Abnormal lipid levels
Or those diagnosed with:
Hypertension
Diabetes mellitus
Kidney disease
Or experiencing:
Risk or aftereffects of myocardial
or cerebral
infarction
Arthralgia or chronic joint pain
Physical decline
frailty
Despite the discomfort or anxiety caused by these conditions,
you can look to the future with:
Maintenance of physical function
Preparation for future decline
Through Midtown Clinic Group’s
Stem Cell Therapy
Early Action against Serious Diseases
To maintain physical function and prevent disease progression
Treatment and Prevention
of Arteriosclerosis
Arteriosclerosis occurs when the endothelial lining of blood vessels is damaged—often due to elevated levels of low-density lipoprotein cholesterol or high blood pressure. This vascular disease can lead to severe conditions, including “angina pectoris,” “myocardial infarction,” “cerebral infarction,” and “cerebral hemorrhage.”
It is particularly important for middle-aged and elderly individuals, or those with suspected lifestyle-related diseases—such as hypertension, dyslipidemia, or diabetes—to take early preventive measures.
Arteriosclerosis is a leading cause of “heart disease” and “cerebrovascular disease,”two of the top causes of death in Japan.
*Source: Ministry of Health, Labour and Welfare, “Overview of Reiwa 1 (2019) Vital Statistics Monthly Report (Preliminary Figures)”
https://www.mhlw.go.jp/toukei/saikin/hw/jinkou/geppo/nengai19/dl/ gaikyouR1.pdf
Arteriosclerosis is characterized by damage inside blood vessels.
In Midtown Clinic Group’s stem cell therapy, a patient’s own stem cells are harvested, cultivated outside the body, multiplied, and then reintroduced. This process aims to repair and regenerate blood vessels, improving symptoms.By reducing inflammation in the vessels, it may also help prevent the progression of the disease.
Treatment and Prevention
of Age-Related Arthralgia
If untreated, age-related arthralgia (joint pain) can worsen, limit mobility, and negatively affect daily life.
Midtown Clinic Group offers stem cell therapy aimed at reducing inflammation and alleviating pain, helping patients maintain their physical activity.
Treatment and Prevention
of Frailty
Midtown Clinic Group provides stem cell therapy to support patients in maintaining physical function and preventing functional decline associated with aging.
Customized Treatment
Using the patient’s own stem cells
Midtown Clinic Group adopts a Personalized approach—cultivating and expanding each patient’s own stem cells for treatment tailored to individual needs.
Customized Stem Cell Therapy
Harvesting Stem Cells from a Small Amount of Tissue
Reducing Physical Burden with Minimal-Volume Harvesting
Treatment with Minimal Impact on Daily Life
At Midtown Clinic Group, stem cells used for treatment are harvested from abdominal fat. The volume collected is equivalent to just 2–3 grains of rice, which places minimal strain on the body. The harvesting procedure takes approximately 20 min, after which the patient can return home immediately. Patients may take a shower or bath the following day, allowing the treatment to have minimal impact on daily life.
What Are Stem Cells?
Cell Production, Tissue Repair,
and Regeneration
Throughout the body—including vital tissues such as bones, blood, and organs—cells are constantly being renewed. Old or damaged cells are routinely replaced with new ones to maintain the body’s overall function and health. The cells responsible for producing and replenishing these lost or damaged cells are known as “stem cells.”They play a crucial role in sustaining the body’s ability to repair itself and maintain proper function.
Stem cells have two primary abilities:
Differentiation Ability: The capacity to become various types of cells that make up the body, such as skin cells, blood cells, nerve cells, and muscle cells.
Self-Renewal Ability: The ability to replicate and produce identical copies of themselves with the same functional capabilities.
The Power of Stem Cells
| Differentiation Ability: | Enables the formation of various types of human cells, including those that make up blood vessels, nerves, and muscles. |
|---|---|
| Self-Renewal Ability: | Allows stem cells to replicate themselves, creating clones with the same capabilities. |
Detecting Damaged Areas
for Automatic Repair and Regeneration
By generating new cells, stem cells can replace those lost due to disease or injury, thereby repairing and regenerating damaged areas.
Stem cells are found throughout the body, but when damaged tissue sends out a signal, stem cells receive it and travel via the bloodstream to the affected area for repair and regeneration.
This natural tendency to gather at damaged sites is known as the “homing effect” (also called auto-tracking), which allows stem cells to automatically detect and target areas in need of regeneration.
Homing Effect
for the Automatic Repair of Damaged Tissue
Stem cells decrease with age.
Stem cell therapy aims
to amplify regenerative ability
The number of stem cells in the body generally decreases with age, although this varies between individuals. Newborns have a large quantity of stem cells, but as we age, both the number of stem cells and their regenerative capacity decline.
Stem cell therapy aims to enhance regenerative ability by cultivating, multiplying, and reintroducing stem cells into the body.
Introduction to Our Center Offering Stem Cell Therapy
Tokyo Midtown Center for Advanced Medical Science and Technology
Located within Tokyo Midtown—a complex featuring a variety of stores, hotels, and art museums—the Tokyo Midtown Center for Advanced Medical Science and Technology offers advanced medical treatments such as stem cell therapy and cancer immunotherapy. We strive to create a relaxing environment for patients, providing concierge services, private consultation spaces, and examination rooms that ensure comfort and privacy.
Center for Advanced Medical Science and Technology
Director
Masamori Shimabuku
Graduated from the Faculty of Medicine, University of the Ryukyus in 1990
After serving as deputy chief of surgery at the University of the Ryukyus Hospital, Naha City Hospital, Northern District Medical Association Hospital, Shinkoga Hospital, and Tomigusuku Central Hospital
August 2015: Joined Tokyo Midtown Advanced Medical Research Institute
2020: Become Vice Director of the Tokyo Midtown Institute of Advanced Medical Research
2024: Appointed Director of Tokyo Midtown Advanced Medical Research Institute
Tokyo Midtown Center for Advanced Medical Science and Technology
An Affiliated Medical Institution of the Midtown Clinic Group
The Midtown Clinic Group works in close cooperation with Tokyo Midtown Clinic, located on the same floor, to provide comprehensive support for patients. We maintain close communication with physicians across a range of specialties to deliver high-quality care. Our services include outpatient medical care such as internal medicine and orthopedics, as well as preventive health services like Ningen Dock and routine health checkups. We also collaborate with external medical institutions to ensure comfortable, well-coordinated treatment experiences. In addition, we are equipped with advanced diagnostic equipment, including CT, MRI, and mammography, to offer specialized examinations.
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80-Row Multi-Slice CT -
3.0 Tesla MRI -
On-site laboratory (clinical testing laboratory) -
Cell Culture Room（Inside Center for Advanced Medical Science and Technology）
Access
Directly connected to Roppongi Station, so you can get there smoothly.
- Address
- Midtown Tower 6F, 9-7-1 Akasaka, Minato-ku, Tokyo 107-6206 Japan (In Tokyo Midtown)
- Tel
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Frequently Asked Questions
Can I receive stem cell therapy at any age?
Are there any side effects?
- Side effects during fat harvesting
- There may be some internal bleeding at the incision site. If you experience any pain, appropriate antipyretics and painkillers will be prescribed.
Can I receive stem cell therapy multiple times?
Are there any circumstances in which I cannot receive stem cell therapy?
・Have a history of malignant tumors (e.g., cancer)
・Have infectious diseases such as HIV or syphilis
・Are undergoing dialysis
・Are pregnant or may be pregnanta
Our physicians will provide detailed guidance during your consultation.